Renewed global interest in the use of nuclear energy for electricity generation, increased threats to the security of nuclear installations, increased use of radioactive materials and the challenges posed by existing nuclear facilities will require new strategies and approaches to safety and security. The aim of this conference, of which this publication is the proceedings, was to enhance international cooperation in the continuous improvement of the regulatory regime for global safety and security and thereby develop a global vision and facilitate future commitments that would lead to fulfilment of this goal.