More on method validation

In XRF spectrometry is common to use in-house developed methods. Method validation is realized by carrying out measurements on appropriate reference material or comparison with results of reliable independent methods. This is due to the fact that result values in certified reference materials are of a higher metrological level than individual laboratory results. Matrix reference materials are the most commonly used.

• Method validation is a process of verifying that a method is fit for purpose, this means fit for solving a particular analytical problem.
  
  
• Method validation is a process of establishing the performance characteristics and limitations of a method and the identification of the influences that may change these characteristics and to what extent. Which analytes can it determine in which matrices in the presence of which interferences?
  
  
• A collaborative study of a method involves practical testing of the written version of the method, in its specific style and format, by a number of laboratories on identical materials.
  
  
• In-house method validation is not a standardized term. It is used in this context to denote the method validation process carried out by one laboratory.
  
  
• Single-laboratory method validation: This term is used when the method is developed and validated in the same laboratory