Method validation
Techniques for the determination of the performance of a method:
- calibration using reference standards or materials
- comparison of results achieved with other validated methods
- interlaboratory comparisons
- systematic assessment of the factors influencing the result
- assessment of the uncertainty based on scientific understanding of the theoretical principles of the method and practical experience
The range and accuracy of the values obtainable from validated methods should include:
- uncertainty of the results
- detection limit
- selectivity of the method
- linearity
- limit of repeatability and/or reproducibility
- robustness against external influences and/or
- cross-sensivity against interference from the matrix as assessed for the intended use, shall be relevant to the clients' needs.