Bone metastases are one of the complications that may arise for cancer patients. Although the management of patients with metastatic bone pain must be a multidisciplinary approach, which includes aspects such as analgesia and hormone treatment, the focus of this publication is irradiation for patients with metastatic bone pain. This publication is a guide for specialists in clinical oncology and should help to improve the clinical management of metastatic bone pain patients treated with radiotherapy and radionuclide therapy.