This CD contains the proceedings of an IAEA Technical Meeting on Issues and Science Relating to Fusion Power Plant Safety. Progress in fusion research and technology over the past two decades has boosted awareness of the potential of fusion to be a lasting and clean source of energy. There is now an increased demand to assess the balance between technological outputs and safety requirements aiming at satisfying the licensing requests for the International Thermonuclear Experimental Reactor (ITER). Efforts in this direction started to develop during the ITER design phases, and the host factor has now been included in it. However, this work represents the beginning of a more challenging process: establishing the safety basis for the licensing of a demonstration fusion power plant (DEMO). During this meeting, major areas of relevance were identified and assessed, and scientific recommendations and guidelines were assembled to determine the direction of future research and development activities towards the licensing of a DEMO power plant. The meeting programme included a total of 28 papers. A summary of the meeting is also included.