Radionuclides continue to play an important role in diagnostic and therapeutic applications in modern nuclear medicine. Many of these radionuclides are produced using cyclotron accelerators, and the corresponding laboratory production methodologies and technologies are subject to constant improvements. This publication summarizes the laboratory protocols developed over a three year period for the production of radionuclides using solid target technology, in particular thallium-201, iodine-123, iodine-124 and palladium-103, which are important radioisotopes for use in medical diagnosis and therapy. This publication is a suitable guide for radioisotope laboratories, cyclotron and radiochemical production facilities, and will be of interest to those dealing with production and applications of radioisotopes and radiopharmaceuticals for nuclear medicine and industrial purposes. A CD-ROM is included.