This publication addresses the management of the chemical toxicity effects of low and intermediate level radioactive wastes. Consideration of chemical toxicity requires an analysis of its impact on the disposal system performance, and the identification of pre-disposal management technologies that support protection of human health and the environment. The document identifies the nature of chemical toxicity contained in LILW, discusses technical options, performance requirements and regulatory aspects in dealing with chemical toxicity, and presents current technical information on applicable waste processing and disposal technologies.