Global climate change and variability are likely to exacerbate plant abiotic stress in the coming decades by increasing water stress and by accelerating soil fertility degradation. To respond to this set of challenges, there is a need to develop agricultural systems with significantly greater productivity and resilience, while at the same time making more efficient use of limited nutrient resources. This publication summarizes the results from a FAO/IAEA coordinated research project (CRP) on optimizing productivity of food crop genotypes in low nutrient environments over a five year period across a wide range of geographical areas and environments.