In recent years, mobile systems have increasingly been deployed for the processing of different types of radioactive waste. Such systems offer flexibility in selection and application of the optimum technology for a specific waste stream by bringing the process to the point where the waste is generated, with the additional benefit that there can be equipment sharing among multiple generating sites. This publication provides the basic information on utilization of mobile systems for waste processing and introduces a methodology for the assessment required to determine the viability of mobile systems for specific applications. In addition, it informs the reader on the accurate assessment of mobile systems that employ one or more technologies. The target audience is professionals involved in the planning, selection, design, deployment and regulation of radioactive waste processing facilities.