This publication details the processes and history of neutron transmutation doping of silicon, particularly its commercial pathway, followed by the requirements for a technologically modern and economically viable production scheme and the current trends in the global market for semiconductor products. It provides guidance on the technical requirements, involved processes and required quality standards for the transmission of sound practices as well as advice for research reactor managers and operators planning commercial scale production of silicon. Furthermore, a detailed and specific database of most of the world’s research reactor facilities in this domain is included, featuring their irradiation capabilities, associated production capacities and processing.