There is a widespread variation in the practices with regard to the release of patients from hospital after unsealed radionuclide therapies. This publication aims to harmonize the different approaches, drawing on new advice issued by the International Commission on Radiological Protection and on a number of regional and national approaches. Particular attention is paid to the most frequent questions from the patients, including those related to potential future pregnancy and the safe approach to reintegration into normal life at home and at work.