This publication describes the procedures for preparing 23 selected Tc-99m radiopharmaceutical kits. Details of the preparation of ten of the active ingredients are also included. The procedures described here can be used to develop manuals, monographs and standard operating procedures. This publication is expected to serve as a guide to radiopharmaceutical manufacturing centres and centralized pharmacies involved in the production of kits. It will be a useful resource for the many hospital radiopharmacies that routinely use the kits to compound Tc-99m radiopharmaceuticals, and a source of information for regulators of radiopharmaceuticals.