Labelling of Small Biomolecules Using Novel Technetium-99m Cores

Technical Reports Series No. 459

Subject Classification: 0101-Nuclear medicine (including radiopharmaceuticals)

English STI/DOC/010/459; (ISBN:92-0-101607-7); 311 pp.; 144 figures; € 70.00; Date Published: 2007

Download PDF (5.75 MB)

Technetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure–activity relationships underlying the biological behaviour of Tc-99m agents. Consequently, careful design of new ligands and their Tc-99m complexes led to the discovery of imaging agents for perfusion in the myocardium and brain, thereby extending the scope of diagnostic imaging using Tc-99m radiopharmaceuticals. Based on the new developments in Tc chemistry, there is good scope for the development of new radiopharmaceuticals for imaging cancer as well as certain specific disease conditions. The IAEA organized a Coordinated Research Project (CRP) with the specific objective to develop labelled biomolecules with the novel Tc-99m metal cores such as the Tc-99m-Carbonyl, Tc-99m-Nitrido, Tc-99m (4+1) and Tc-99m-HYNIC cores. The preparation, quality assessment and biological evaluations of a large number of Tc-99m complexes with biomolecules such as RGD peptides, annexin derived peptides, fatty acid derivatives, quinazoline derivatives and glucose analogues were achieved by the participants during the CRP. The results obtained from the participating laboratories are summarized in this publication.

Download Order Form PDF
You might also like

Cyclotron Produced Radionuclides: Emerging Positron Emitters for Medical Applications: 64Cu and 124I ...

IAEA Radioisotopes and Radiopharmaceuticals Reports - 1

EnglishSTI/PUB/1717

(ISBN:978-92-0-109615-9)

Read more

Good Practice for Introducing Radiopharmaceuticals for Clinical Use ...

IAEA TECDOC - 1782

EnglishIAEA-TECDOC-1782

(ISBN:978-92-0-111215-6)

Read more

Quality Management Audits in Nuclear Medicine Practices ...

IAEA Human Health Series - 33

EnglishSTI/PUB/1683

(ISBN:978-92-0-101715-4)

Read more

Radiopharmaceuticals for Sentinel Lymph Node Detection: Status and Trends ...

IAEA Radioisotopes and Radiopharmaceuticals Series - 6

EnglishSTI/PUB/1674

(ISBN:978-92-0-109714-9)

Read more

Yttrium-90 and Rhenium-188 Radiopharmaceuticals for Radionuclide Therapy ...

IAEA Radioisotopes and Radiopharmaceuticals Series - 5

EnglishSTI/PUB/1662

(ISBN:978-92-0-103814-2)

Read more

IAEA Syllabus for the Education and Training of Radiation Oncologists ...

Training Course Series - 36

ArabicIAEA-TCS-36

Read more

IAEA Syllabus for the Education and Training of Radiation Oncologists ...

Training Course Series - 36

RussianIAEA-TCS-36

Read more

IAEA Syllabus for the Education and Training of Radiation Oncologists ...

Training Course Series - 36

SpanishIAEA-TCS-36

Read more

Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods ...

IAEA Human Health Reports - 9

EnglishSTI/PUB/1605

(ISBN:978-92-0-141510-3)

Read more

IAEA Syllabus for the Education and Training of Radiation Oncologists ...

Training Course Series - 36

FrenchIAEA-TCS-36

Read more

Standard Operating Procedures for PET/CT: A Practical Approach for Use in Adult Oncology ...

IAEA Human Health Series - 26

EnglishSTI/PUB/1616

(ISBN:978-92-0-143710-5)

Read more

Practical Guidance on Peptide Receptor Radionuclide Therapy (PRRNT) for Neuroendocrine Tumours ...

IAEA Human Health Series - 20

EnglishSTI/PUB/1560

(ISBN:978-92-0-129210-0)

Read more

Cyclotron Produced Radionuclides: Operation and Maintenance of Gas and Liquid Targets ...

IAEA Radioisotopes and Radiopharmaceuticals Series - 4

EnglishSTI/PUB/1563

(ISBN:978-92-0-130710-1)

Read more

Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of Fluorodeoxyglucose (FDG) ...

IAEA Radioisotopes and Radiopharmaceuticals Series - 3

EnglishSTI/PUB/1515

(ISBN:978-92-0-117310-2)

Read more

Production of Long Lived Parent Radionuclides for Generators: 68Ge, 82Sr, 90Sr and 188W ...

IAEA Radioisotopes and Radiopharmaceuticals Series - 2

EnglishSTI/PUB/1436

(ISBN:978-92-0-101110-7)

Read more