Reactors worldwide have produced more than 2000 tonnes of plutonium, contained in spent fuel or as separated forms through reprocessing. Disposition of fissile materials has become a primary concern of nuclear non-proliferation efforts. There is a significant interest in IAEA Member States to develop proliferation resistant nuclear fuel cycles for incineration of plutonium, such as inert matrix fuels (IMFs). This publication reviews the status of potential IMF candidates and describes several identified candidate materials for both fast and thermal reactors some of which have undergone test irradiations and post-irradiation examination. Also discussed are modelling of IMF fuel performance and safety analysis.