This publication reports on the International Project on Innovative Nuclear Reactors and Fuel Cycles, referred to as INPRO, which was initiated by the IAEA in 2000. The main objectives of INPRO are: to help to ensure that nuclear energy is available to contribute to fulfilling energy needs in the 21st century in a sustainable manner; and to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles.