This manual has been developed to assist plant managers in fulfilling their responsibility with regard to the control and direction of quality and quality assurance activities in nuclear power plant operation. It emphasizes quality objectives for nuclear power plant operations and gives highlighted practices complemented by typical examples of forms and procedures. The selected activities comprise those where it was felt that practical advice is generally needed. Contents: 1. Introduction; 2. Quality management; 3. Competence of personnel; 4. Operations; 5. Maintenance; 6. Deficiencies and corrective actions; 7. Technical support; 8. Radiological safety; 9. Emergency preparedness; 10. Feedback; Appendix A: Summary of plant superintendent’s involvement and reviews listed in the manual; Appendix B: Typical organization of nuclear power plant operations, showing the functions allocated to superintendents and managers; Annexes I–XXI.